B vitamins for depression – a product review

It is becoming more widely known that it is very beneficial to take B Vitamins for depression.  There are a huge range of Vitamin B products on the market however, both on their own and in complex formulas.  Before we review which are the better products, we need to know what we require from them.

Here is a simple breakdown of which B vitamins we’ll be looking for.

B1 (Thiamine)

Loss of Thiamine causes neurological damage, such as numbness and tingling, as well as mental symptoms including memory loss, confusion, nervousness and poor concentration.  Severe deficiency causes beriberi, or Wernicke-Korsakoff syndrome, an irreversible brain deterioration seen in alcoholism.

B3 (niacin, or nicotinamide)

A growing body of evidence highlights the key role of vitamin B3 in neuronal health. Although more research is still outstanding, there is enough evidence to confirm that a lack of B3 can cause depression, amongst other conditions. There is also a fast growing body of evidence suggesting that B3 supplementation can massively reduce symptoms of anxiety and depression.

B5 (Pantothenic Acid)

Vitamin B5 plays an essential role in the structure and function of brain cells via its involvement in the synthesis of cholesterol, amino acids, phospholipids, and fatty acids.

B6 (Pyridoxine)

Even a mild deficiency of B6 results in preferential down-regulation of GABA and serotonin synthesis. GABA is the amino acid that regulates anxiety in your body, and serotonin allows our bodies to absorb the feel-good hormone dopamine.

B12 (Cobalamin)

Higher total intakes, which included supplementation, of vitamins B-6 and B-12 are associated with a decreased likelihood of incident depression for up to 12 years into the studies.  For example, each 10 additional milligrams of vitamin B-6 and 10 additional micrograms of vitamin B-12 were associated with 2% lower odds of depressive symptoms per year. There was no association between depressive symptoms and food intakes of these vitamins or folate.

Which basically means, that taking more B12 decreases your chances of having depression.

I have had a look at three products which contain the suggested vitamins to improve depression, fatigue and anxiety.  You can of course find these anywhere, but please take care to note the amounts of each component, and make sure that the various vitamins are contained in the product.

B vitamins for depression

Nature’s Plus Mega B-150 – 60 Tablets
Nature's Plus Mega B-150 - 60 Tablets

With high dosages of B 1, 3, 5, 6 and 12,  Nature’s Plus Mega B-150 ticks the right boxes for composition. I am a little concerned however about how high the dosages are.  Not all the B vitamins have Upper Intake Levels (how much is safe to take), but some do.  B6 for example can become toxic at 300mg daily.

This bottle contains 60 tablets, so 2 months supply which is handy.

Does it tick the boxes?

Gluten Freex
Dairy Freex



Twinlab Stress B Complex

A bottle of stress Bingredients of StressBComplex

Stress B-Complex from TwinLab contains ideal amounts of the B Complex vitamins, and has the added benefit of 1000mg vitamin C.

With 100 tablets in this bottle, it also ticks the box for affordability.





Now Foods B-100 

a bottle of B100 from now foods  

Now Foods B-100 compares very well with the other reviewed supplements.  I specifically like the affordability, as the bottle contains 250 capsules.

Does it tick the boxes?

Gluten Freex
Dairy Freex

At present, the TwinLab Stress B-Complex is my preferred choice for the simple reason that I don’t have to add vitamin C as an extra supplement. If you’d like more information about the best Vitamins for Depression, you can read more here:

The Best Vitamins for Depression

I’ve picked these items based on the quality of the products. We partner with some of the companies that sell these products, which means samsavageonline.com may receive a portion of the revenues when you buy something using the links above.


1. B Vitamins and the Brain: Mechanisms, Dose and Efficacy—A Review https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772032/
Keep up with new articles by Sam
Sign up to recieve a copy of new articles via email
We will not share your personal details with anyone... ever.


  1. Kozakiv

    Vitamins B are for better memory – there is a wealth of evidence to support the thesis that adequate vitamin B status is very important for the development and maintenance of a person’s mental function. Studies have shown that vitamins B6, B12 and folic acid can reduce the risk of developing dementia and Alzheimer’s. These same vitamins play an important role in the synthesis of neurotransmitters important for cognitive and other brain functions.Thank you for the post on Vitamin B.

    • Sam Savage

      Thanks so much for your comment!

      Indeed, we agree. I read a research article where they proved that for every 10mg of B Complex a person took, their chance of altzheimers reduced with 10%.

      Amazing stuff! 

  2. Rhain

    There’s no denying or neglecting the importance of vitamin B in our well-being. I must say though, this article has provided even more clarity for me on its vitality. The profound effect thiamine alone has on the health is simply mind-boggling. It plays an undeniable role in most of our neurological functions. Like you, I think the twinlab B complex is ideal since it does not require additional vitamin c and it is also affordable.

    Thanks for sharing. 

    • Sam Savage

      Hi Rhian

      Thanks so much for your comment! 

      I love to speak to new people who share the understanding of what vitamins can do for us. 

      Happiness to you. 

  3. Leon

    B vitamins are really essential when it comes to helping depression and anxiety. Scientist found that people could really respond fast to treatment if B12 at higher levels is found in their blood. Of course, researchers believe that B vitamins supplements could help to possibly treat people suffering from depression. Other than that, vitamin B plays a very significant role in our body. You’ve done a good job of listing some helpful natural supplements that could be used to help people in this situation.

    • Sam Savage

      Hi there

      Yes, it’s great to see all the scientific studies coming out that prove the value of vitamins for depression. It’s not just theory any more its fact. 

      Thanks so much for your comment. 

  4. MrBiizy

    Dear Sam, I am so surprised at the huge list of B Vitamins deficiency and I am happy that you were able to come up with the ones we can take to live a life free of depression and anxiety. I remembered when I was a little boy, I was taught a popular deficiency of Vitamin B1 which is beriberi. I learnt a whole lot from this and what what to look out for when choosing a B Vitamin to purchase. 👍🏽

    • Sam Savage

      Hi there

      Yes, although people in the west are not familiar with Beriberi, I saw a lot of it in Zambia during hunger times. Those children have massive problems with brain development and growth too. 

      Its so sad. 

      Thanks so much for your comment. 

Leave a Reply

Your email address will not be published. Required fields are marked *